There are three naturally occurring tetracyclines (oxytetracycline, chlortetracycline, and demethylchlortetracycline) and several that are derived semisynthetically (tetracycline, rolitetracycline, methacycline, minocycline, doxycycline, lymecycline, etc). Elimination times permit a further classification into short-acting (tetracycline, oxytetracycline, chlortetracycline), intermediate-acting (demethylchlortetracycline and methacycline), and long-acting (doxycycline and minocycline). The newest class of tetracycline-related antimicrobials are the glycylcyclines, represented by tigecycline, which contains a bulky side chain compared with minocycline.
The tetracycline group is currently used to treat goats for diseases such as mastitis, pink eye, and urinary and enteric infections (Pharmacia and Upjohn, 1998). They are generally regarded as relatively nontoxic, but they could produce a large number of adverse effects, some of which can be life threatening under certain circumstances. Those effects include superinfection, diarrhea, ingestion, direct toxicity, irritation, dizziness, antianabolic effects, photosensitivity, and allergic symptoms in humans.
Features of Tetracycline For Goats
All of the tetracycline derivatives are crystalline, yellowish, amphoteric substances that, in aqueous solution, form salts with both acids and bases. They characteristically fluoresce when exposed to ultraviolet light. The most common salt form is the hydrochloride, except for doxycycline, which is available as doxycycline hyclate or monohydrate. The tetracyclines are stable as dry powders but not in aqueous solution, particularly at higher pH ranges (7–8.5). Preparations for parenteral administration must be carefully formulated, often in propylene glycol or polyvinyl pyrrolidone with additional dispersing agents, to provide stable solutions.
Tetracyclines form poorly soluble chelates with bivalent and trivalent cations, particularly calcium, magnesium, aluminum, and iron. Doxycycline and minocycline exhibit the greatest liposolubility and better penetration of bacteria such as Staphylococcus aureus than does the group as a whole. This may contribute to their efficacy in treatment of gingival diseases that may be associated with bacterial glycocalyx. Tigecycline is a glycylcycline derivative of minocycline; its large side chain decreases the risk of resistance.
Oxytetracycline is an antimicrobial agent that is effective in the treatment of a wide range of diseases caused by susceptible gram-positive and gram-negative bacteria, rickettsia and mycoplasma, like respiratory, intestinal, dermatological, genitourinary and septicemic infections in cattle, sheep, goats, pigs etc.
For Intramuscular or subcutaneous injection.
Cattle and Horse:1~2.5ml per 100kg body weight
Pig, Sheep and Goat: 0.25ml per 10kg body weight
Pig,Dog, Piglet and Lamb: 0.1~0.25ml per 5kg Body weight
Poultry: 0.25~0.5ml per hen
Meat : 14days.
Milk :3days (6 milkings)\
Prices of Tetracycline For Goats
$18.03 – $51.99 –