Swine dysentery is a disease of global significance that leads to large losses in pig production. At present, treatment of the disease involves the use of antibiotics in a race against the development of resistances to new emerging strains. The fact that cultivation of Brachyspira hyodysenteriae, is complex, in combination with the lack of strains with a representative number of isolates, presents a barrier to the development of a universal vaccine. Consequently, it is difficult to control this highly contagious disease which eventually infects the majority of the animals on the farm and whose control entails considerable economic losses.
Between 2000 and 2012 the Brachyspira research group, located in the department of Infectious Diseases of the Faculty of Veterinary Medicine of León, has investigated more than 1,000 diarrhea outbreaks on pig farms, mainly in Spain and Portugal, but also in other European countries. Swine dysentery has been diagnosed in a high number of these outbreaks which facilitated the large collection of field isolates available to the department today. In March 2012, when the company was set up, the Brachyspira hyodysenteriae, strains were transferred to Aquilón for use in the development of a vaccine to improve the control of this important disease.
A vaccine prototype, that has been patented and demonstrated efficacy in controlled infection tests, is now available. Industrial scale-up, one of the most critical points during the development process, has been successfully completed. The vaccine’s efficacy and safety are currently being confirmed in the first preclinical regulatory trials that will allow the presentation of a licensable product to interested laboratories before demonstrating its efficacy in field outbreaks.
No commercially available vaccines exist for the control of swine dysentery, unfortunately. “The only way we have to control and prevent it, or even try to eradicate it, is with antibiotics,” Costa said. “We can depopulate and try to get rid of it that way, but it’s very hard to keep it out of the barn. Rodents can keep the bacterium alive and shed it, he explained. Birds can also be carriers, and the bacterium can survive in organic matter. It’s a challenging task, but living with the problem is not a viable option, Costa said.
Features of Swine Dysentery Vaccine
The present invention relates to a composition comprising Brachyspira hyodysenteriae bacteria, particularly in the field of immunization against swine dysentery. The composition of the invention comprises bacteria from at least two genetically diverse strains of B. hyodysenteriae. The invention relates also to the composition of the invention for use as a vaccine, preferably a universal vaccine against swine dysentery caused by B. hyodysenteriae.
Prices of Swine Dysentery Vaccine
$40.95 – $95.15