Sulfamethazine is a sulfa drug used to treat bacterial diseases in humans and animals, and to promote growth in cattle, sheep, pigs, and poultry. The U.S. Food and Drug Administration (FDA) has established a tolerance of no more than 0.1 parts per million (PPM) for residues of sulfamethazine in the uncooked edible tissues of cattle. This bolus may be divided for better approximation of correct dose; however, care should be taken not to crush the bolus. Care should also be taken to ensure the entire dose has been swallowed by the animal. Observe animals following administration to ensure boluses are not regurgitated. Lubricate bolus before dosing animals.
Supra Sulfa® III Boluses are designed to provide a therapeutic sulfamethazine level in approximately 6 hours and persist in providing this level for 72 hours (3 days). After 72 hours, all animals should be re-examined for persistence of observable disease signs. If signs are present, consult your veterinarian. It is strongly recommended that a second dose be given to provide for an additional 72 hours of therapy, particularly in those more severe cases. The dosage schedule should be used at each 72-hour interval.
Sulfonamides are organic sulfur compounds that contain the radical SO2NH2. They are used as antibiotics to treat bacterial infections in humans and animals. Sulfonamides work by interfering with a bacterium’s production of folic acid, which the bacterial cell needs for energy and reproduction. Sulfonamides have a limited effect on animal cells, which do not synthesize their own folic acid. Whether administered in feed, in water, by injection, or by mouth, sulfonamides are distributed throughout the body and into the soft tissues, including the cerebrospinal fluid and joints, and are excreted in the urine. In animals, sulfonamides are used to treat conditions such as bacterial pneumonia, bacterial scours, coccidiosis, foot rot, calf diphtheria, acute mastitis and acute metritis.
Dosage and Administration
Supra Sulfa® III Boluses (Sulfamethazine Sustained Release Boluses) are designed to be administered orally to beef cattle and non-lactating dairy cattle (See Warning). Supra Sulfa® III Boluses should be give according to the following dosage schedule: