Pyrantel is a narrow-spectrum anthelmintic effective against gastrointestinal roundworms but not against those in the lungs or elsewhere in the host’s body. At higher doses it is also effective against certain tapeworms as well. It is ineffective against flukes (e.g. Fasciola hepatica). It is completely ineffective against external parasites.The efficacy of pyrantel tartrate was evaluated in goats against induced infections with Haemonchus contortus, Teladorsagia circumcincta and Trichostrongylus colubriformis. All the strains were of sheep origin and tested for susceptibility to pyrantel tartrate in sheep at the standard dose rate (20 mg kg-1) prior to the infection of goats. Fifteen French Alpine female goats were inoculated with the three nematode species.
Pyrantel Pamoate Suspension 50 mg 32 oz bottle
Brands may vary
Oral administration is the rule. It is used very scarcely in livestock but quite a lot in dogs and cats (often in tablets, pills, etc. or oral suspensions) and also in horses (mostly in oral pastes & gels). There are hundreds of generic brands worldwide, also in mixtures with other anthelmintics. It is also used as a human medicine. It is not used against agricultural or household pests.
Pyrantel is used in the form of different salts, e.g. chlorhydrate, tartrate and pamoate (=embonate). Efficacy depends on the content of so-called “pyrantel base”. 10 mg pyrantel base correspond to 11.5 mg pyrantel chlorhydrate; 17.22 mg pyrantel tartrate; and 29 mg pyrantel pamoate (=embonate). The tartrate is water-soluble but is unstable in solutions. The pamoate (=embonate) is not soluble in water.
recommendations for antiparasitics depend on national regulations. National regulatory authorities determine whether a product is approved for a given indication, i.e. use on a particular host at a specific dose and against a specific parasite. Check the labels of the products available in your country for specific information on approved indications.