The penicillins are among the earliest classes of antibacterial drugs. Penicillins are divided into subclasses based on chemical structure (eg, penicillins, monobactams, and carbapenems), spectrum (narrow, broad, or extended), source (natural, semisynthetic, or synthetic), and susceptibility to β-lactamase destruction. Manipulation of some drugs has improved the spectrum, resistance to β-lactamase destruction, or clinical pharmacologic characteristics that enhance efficacy.
Penicillin Injectable is a suspension of penicillin G procaine in 100, 250, and 500 mL multiple dose vials. Each mL is designed to provide 300,000 units of penicillin G as procaine in a stable suspension. Penicillin G procaine is an antibacterial agent which has activity against a variety of pathogenic organisms, mainly in the Gram-positive category.
Inject deep into the muscle every 24 hours. Continue treatment for 1-2 days after symptoms disappear. If no improvement is noted within 36-48 hours re-evaluate the diagnosis. Mild soreness may result following subcutaneous administration. This suspension should never be administered intravenously.
Give 6,000 i.u. per Kg of body weight (1 mL/50 Kg). Increase the dose to 12,000 i.u. – 18,000 i.u. per Kg for serious infection (2-3 mL/50 Kg).
1 – 10 Kg
10 – 20 Kg
1/4 – 1/2 mL
20 – 50 Kg
1/2 – 1 mL
50 – 100 Kg
1 – 2 mL
100 – 200 Kg
2 – 4 mL
200 – 400 Kg
4 – 8 mL
As with all veterinary drugs, the use of Procaine Penicillin G + Benzathine Penicillin Injection can cause adverse reactions. Always consult a veterinarian or animal care specialist for medical advice before use. With very high overdoses, a decreased immune response can be observed. Common adverse reactions may include abortion in sows (in case of overdose), ototoxicity, neurotoxicity or nephrotoxicity.
If you notice any serious adverse reactions or other reactions not listed on this package, please inform your veterinarian. For a complete list of all possible effects, consult a veterinarian. If any of the symptoms persist or worsen, or if you notice any other symptoms, please seek veterinary medical treatment immediately.