Praziquantel is a narrow-spectrum anthelmintic effective basically against tapeworms and a few specific fluke species (e.g. Eurytrema pancreaticum, Schistosoma spp). It is ineffective against any kind of roundworms and external parasites. is the most used taenicide in dogs and cats (mainly in the form of tablets, pills, etc, oral suspensions and a few injectables) as well as horses (mostly in oral pastes & gels), very frequently combined with an appropriate nematicide (e.g. ivermectin, pyrantel). There are hundreds of generic brands containing praziquantel worldwide. Use in ruminants or swine is marginal. Praziquante is also used as a human medicine. It is not used against agricultural or household pests. Praziquantel has almost no residual effect, i.e. it kills the parasites during a few hours after treatment but offers no significant protection against re-infestation.
Praziquantel is an anthelmintic from the pyrazinisoquinoline group. It causes a wide spectrum of action in relation to most species of pathogens of trematodoses that are pathogenic for mammals: opisthorchiasis, metorchiasis, clonorchiasis (Opisthorchiidae family), schistosomiasis (Schistosomatidae family), paragonimiasis (Paragonimidae family), etc .; as well as regarding the causative agents of intestinal cestodoses: in sheep and goats from the family Anoplocephalidae (Moniezia spp.), Avitellinidae (Thysaniezia giardi, Avitellina centripunctata, Stilesia spp.), acts on the early stages of most laurel cestodoses; in carnivores – from the family Taeniidae (Taenia spp., Echinococcus spp.), Dilepididae (Dipylidium caninum), Mesocestoididae (Mesocestoides spp.), Diphyllobothriidae (D. latum, D. minus).
Features of Praziquantel For Sheep
The combination of two active substances: closantel and praziquantel, provides a wide spectrum of anthelmintic action in relation to the main most common causative agents of nematodes, cestodoses and trematodes, as well as a size of causative agents of arachnoentomoses, which parasitize sheep, goats and dogs. Closantel is a synthetic compound derived from the salicylanide group. Its action causes the inhibition and arrest of the process of electron transfer, which leads to changes in the energy metabolism of parasites and leads to their further death. As a highly effective anthelmintic, closantel acts on larvae and sexually mature nematodes (especially hematophages), arthropod trematodes:
in sheep and goats against strongylatosis of the gastrointestinal canal (Bunomostum spp., Haemonchus spp., Nematodirus spp., Oesophagostomum spp., Trichostrongylus axei, Chabertia ovina, etc.) and trematodes (Fastiola hepatica, Dumcoelanceium , Eurytrema pancreaticum, etc.); in dogs against ankylostomatidosis of the Ancylostomatidae family (Ancylostoma caninum, A. braziliense, Uncinaria stenocephaia, etc.); in these animal species against arthropods in the larva-imago phase of different localization of parasitism: Oestrus ovis, Crivellia silenus, Wohlfahrtia magnifica, W. trina, Lucilia sericata, Bovicola ovis, B. caprae, Melophagus ovinus, Linognathus ovillus, L. caprae, L. setotus, Trichodectes canis and the like, scabies mites of the families Psoroptidae, Sarcoptidae, Demodecidae, ixodid mites and the like.
This product is a broad spectrum anthelmintic for use in the treatment and control of nematode and cestode infections in sheep. It is highly effective against mature and developing immature forms of nematodes, including lungworms and against adult forms of tapeworm in sheep. It should be used in cases of parasitic gastro-enteritis and lungworm disease caused by those organisms sensitive to treatment with praziquantel and levamisole hydrochloride.