Praziquantel is a narrow-spectrum anthelmintic effective basically against tapeworms and a few specific fluke species (e.g. Eurytrema pancreaticum, Schistosoma spp). It is ineffective against any kind of roundworms and external parasites. It is the most used taenicide in dogs and cats (mainly in the form of tablets, pills, etc, oral suspensions and a few injectables) as well as horses (mostly in oral pastes & gels), very frequently combined with an appropriate nematicide (e.g. ivermectin, pyrantel). There are hundreds of generic brands containing praziquantel worldwide. Use in ruminants or swine is marginal.
Praziquante is also used as a human medicine. It is not used against agricultural or household pests. Praziquantel has almost no residual effect, i.e. it kills the parasites during a few hours after treatment but offers no significant protection against re-infestation.
Praziquantel is an anthelmintic from the pyrazinisoquinoline group. It causes a wide spectrum of action in relation to most species of pathogens of trematodoses that are pathogenic for mammals: opisthorchiasis, metorchiasis, clonorchiasis (Opisthorchiidae family), schistosomiasis (Schistosomatidae family), paragonimiasis (Paragonimidae family), etc .; as well as regarding the causative agents of intestinal cestodoses:
in sheep and goats from the family Anoplocephalidae (Moniezia spp.), Avitellinidae (Thysaniezia giardi, Avitellina centripunctata, Stilesia spp.), acts on the early stages of most laurel cestodoses; in carnivores – from the family Taeniidae (Taenia spp., Echinococcus spp.), Dilepididae (Dipylidium caninum), Mesocestoididae (Mesocestoides spp.), Diphyllobothriidae (D. latum, D. minus).
Praziquantel Injection is absorbed, metabolized in the liver and excreted via the bile into the digestive tract where its cestocidal activity is exerted1. Following exposure to praziquantel, the tapeworm loses its ability to resist digestion by the mammalian host. Because of this, whole tapeworms, including the scolex, are very rarely passed after administration of praziquantel. It is common to see only disintegrated and partially digested pieces of tapeworms in the stool. The majority of tapeworms killed are digested and are not found in the feces.
Praziquantel Injection Cestocide may be administered by either the subcutaneous or intramuscular route to dogs and cats. The recommended dosage of praziquantel varies according to body weight. Smaller animals require a relatively larger dosage. The optimum dosage for each individual animal will be achieved by utilizing the following dosage schedule.