Piperazine For Chickens

Piperazine is the only FDA approved dewormer for use in laying hens in the United States. It is only effective against the adult large roundworm. It has no effect on any other species of worms, including tapeworms. Piperazine can be given orally by mouth in each bird, or added to the flock’s water source. Treatment needs to be repeated in 7-10 days since the drug does not kill the large roundworm eggs. If given by mouth: 50 mg/bird (if younger than 6 weeks of age), otherwise 100 mg/bird (if older than 6 weeks of age), or according to the manufacturer label. Repeat in 7-10 days. If added to flock water source: 3 mL per gallon of water, or in accordance with the manufacturer’s label. Repeat in 7-10 days. Egg Withdrawal Period: In Australia and Canada, piperazine is approved for 1-time use in egg laying hens at doses ranging from 130 to 200 mg/kg (59 to 91 mg/lb) with a 0-day egg withdrawal. Storage/Stability: Unless otherwise specified by the manufacturer, piper­azine products should be stored


Piperazine dihydrochloride is an anthelmintic for use in drinking water or feed. Piperazine dihydrochloride is a hygroscopic, alkaline chemical, well soluble in water. Piperazine is a selective agonist of gamma-amino butyric acid (GABA) receptors, resulting in the opening of chloride channels and hyperpolarisation of the membrane of the muscle cells of the nematode parasite. The hyperpolarisation causes nerve membranes to block at the neuromuscular junction, causing paralysis to the nematodes which are then excreted with the faeces.

Dosage and administration

For oral administration via feed or drinking water.

  • Broilers:
    Age in weeks          g of Piper Dewormer wsp in 1,000 litres drinking water
    1 – 2                        195 g daily during 2 days
    3 – 4                         270 g daily during 2 days
    5 – 6                         360 g daily during 2 days
    This is equivalent to 32 mg piperazine per kg bodyweight.
  • Layers : 760 g Piper Dewormer wsp in 1,000 litres drinking water, daily during 2 days. This dosage is based on layers with a bodyweight of 2,5 kg and a water uptake of 210 ml per animal per day. This is equivalent to 32 mg piperazine per kg bodyweight
  • Cattle, horses, pigs : 2,2 g Piper Dewormer wsp per 10 kg bodyweight, equivalent to 110 mg of piperazine base per kg bodyweight.

Anthelmintic activity is directly related to the proportion of free base, which is in Piperazine dihydrochloride 50%. Mixed with feed, the product should be used immediately. Medicated drinking water should be used within 24 hours. Treatment can be repeated within 30 – 45 days.

Uses/benefits of Piperazine For Chickens

The piperazine salts are used for the treatment of ascarids in dogs, cats, horses, pigs and poultry. Piperazine Kyron is a white crystalline powder consisting of I 00% piperazine adipate (=37% piperazine base). Piperazine acts by altering muscular polarisation in susceptible nematodes, thereby paralysing the worm and allowing it to be passed out with the faeces. This neuromuscular effect is believed to be caused by blocking acetylcholine at the myoneural junction. In ascarids, succinic acid production is also inhibited. Piperazine adipate is readily absorbed from the proximal sections of the GI tract and the drug is metabolised and excreted by the kidneys. Piperazine compounds have a wide margin of safety in all animals.

Side effects

Overdoses can cause colic, coughing, excessive salivation, excitation, hyperpnoea, lachrymation, spasms, sweating and vomiting.

Withdrawal Period:

  • Meat : 3 days
  • Eggs : 2 days

Prices of Piperazine For Chickens

$18.06 – $33.96

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