One of the most important health problems in rabbit is pasteurellosis, which is considered as a common bacterial disease caused by Pasteurella multocida (P. multocida) and has been reported as a constant serious and highly contagious disease of domestic rabbits Rabbit pasteurellosis causes symptoms that range from fatal septicemia, severe pleuritis, and pneumonia to less severe sequelae such as multiple abscesses, chronic rhinitis, and otitis media It mostly affects rabbits at 4–8 weeks of age. Rabbits older than 8 months to 1 year of age showed lower incidence .
Pasteurellosis exhibited 3 forms in rabbits. The first one is snuffles or nasal catarrhal inflammation which is characterized by acute, subacute, and chronic inflammation of the air passages and lungs. This form of the disease often ends with death and the cured animals became carriers. The second form is characterized by abscess formation at any part of the body and the case is terminated with septicemia. The last form is characterized by genital infection, which manifests as acute and subacute inflammation of uterus and testicles. Also, rhinitis is the most common clinical manifestation in rabbit pasteurellosis ].
Initially, the intent was to develop a vaccine for use in the lab herd only. But while Mr. Glass could readily see the commercial potential of a vaccine which would be available to the general public, it took a couple years to convince the Lab’s management that a bunny vaccine was important. The application was submitted to the USDA, along with the pre-clinical trials that had already been done very successfully. A clinical trial followed. For this blinded study, 30 rabbits were divided into 3 groups. Group A received vaccine A, Group B received vaccine B, while group C received a placebo. The study administrators however did not know which group was which. The vaccines were administered on day zero and day 28. The challenge was administered 3 weeks after the second vaccination.
- 100% of the control group developed severe pneumonia due to Pasteurella
- 60% of the control group rabbits died from subsequent pasteurella infection.
- Zero animals died from the vaccinated groups
- A small number of animals in the vaccinated groups showed slight nasal congestion and clear nasal discharge for 24-48 hours as may be expected when the immune response defeats a potential infection.
Features of Pasteurella Vaccine For Rabbits
Pasteurella multocida is bacteria that commonly causes abscesses, respiratory infections, and chronic inflammatory disease in rabbits. It can infect the nasolacrimal (tear) ducts, eyes, ears, and nose, and can cause abscesses of tooth roots, bones (particularly the jaw), skin, tissues under the skin, and internal organs. This organism commonly causes an upper respiratory tract infection often called snuffles which frequently occurs in young rabbits.
Many cases of snuffles are mild, involving slight ocular or nasal discharge and sneezing and, if caught early, can be effectively treated or managed. If left untreated, this infection can progress to become severe, chronic, and potentially fatal. A swab for bacterial culture and antibiotic sensitivity testing can be taken of ocular or nasal discharge to help guide treatment. Treatment usually involves either oral or injectable antibiotics, given for a minimum of 2-4 weeks. In some cases, treatment can be required for months depending on the response to therapy.
Benefits of Pasteurella Vaccine For Rabbits
There are four major infectious diseases seen in pet rabbits. Two serious diseases caused by viruses rarely seen in indoor pets, are myxomatosis and viral hemorrhagic disease. Because they are viral diseases, there are no effective treatments once the rabbit is infected. Two other infectious diseases of rabbits are encephalitozoonosis (a neurologic disease caused by the parasite Encephalitozoan cuniculi) and respiratory infection caused by the bacteria Pasteurella multocida. These are common in indoor pet rabbits.
Mode of action
BunnyVac contains millions of killed Pasteurella bacterium which, when injected into a rabbit, cause an immune response identical to that seen in infected rabbits. However, since BunnyVac is a killed bacterial product, no infection occurs. Instead the rabbit develops an immune e response that is able to prevent a real infection in the future.
Prices of Pasteurella Vaccine For Rabbits