Lyme Vaccine For Dogs

An initial Lyme vaccine can be given as early as 8-9 weeks of age (depending on the manufacturer). After the initial vaccine, a booster vaccine must be given 3-4 weeks later. The dog is considered to be protected against Lyme disease four weeks after receiving the second Lyme vaccination. 

For long-term protection, the Lyme vaccine must be repeated once annually for the remainder of your dog’s life. If your dog is significantly overdue for its annual booster, your veterinarian may recommend restarting the initial two-vaccine series. Vaccinations trigger a response from the immune system. Therefore, mild side effects are normal and expected. Expected effects may include a mild fever, lethargy, soreness at the site of the vaccine, and decreased appetite. Just like when you get a flu shot, your dog’s response to a vaccine may result in mild, short-lived signs of illness.  Occasionally, more serious reactions occur. Although severe vaccine reactions are rare, they require quick action. These reactions indicate an allergic reaction to a component of the vaccine. 


The first and only chimeric recombinant canine Lyme disease vaccine. VANGUARD® crLyme helps provide broad-spectrum coverage against outer surface protein A (OspA), found in the tick, and contains antigens from multiple types of outer surface protein C (OspC), found in the tick and dog. Indication: For vaccination of healthy dogs 8 weeks of age or older as an aid in the prevention of clinical disease and subclinical arthritis associated with Borrelia burgdorferi. Administration: 1 mL subcutaneous vaccine; dogs should be administered two doses, three weeks apart; annual revaccination recommended.

Features of Lyme Vaccine For Dogs

  • Lyme vaccine designed to target the 2 key outer surface proteins (Osps) involved in disease transmission for a full level of protection
  • Proven to induce borreliacidal antibodies that bind to OspA and OspC, forming a complex that attacks the cell membrane and kills Borrelia burgdorferi 
  • Proven to help prevent clinical disease such as arthritis – as well as at the subclinical level 
  • High level of protection: no serologic evidence of exposure to Borrelia burgdorferi following challenge with infected
    I. scapularis ticks

Signs of an allergic reaction to Lyme vaccination include:

  • Vomiting
  • Diarrhea
  • Hives
  • Facial swelling
  • Excessive itching (often of the face)
  • Trouble breathing
  • Extreme lethargy or weakness
  • Collapse (due to anaphylactic shock)

If your dog experiences a vaccine reaction, contact your veterinarian immediately. Your veterinarian will help you determine whether your pet’s reaction can be managed at home or whether your dog needs emergency treatment. Once the immediate reaction has been addressed, your veterinarian will talk about future plans to decrease the likelihood of a similar reaction in the future.


Shown to be effective for vaccination of healthy dogs 8 weeks of age or older against Borrelia burgdorferi. Duration of Immunity is at least 1 year. Also been shown to be effective against subclinical arthritis caused by Borrelia burgdorferi.

Dosage and administration

  • Subcutaneous injection
  • Two 1 mL doses given 2 to 4 weeks apart
  • Contact your veterinarian or manufacturer for more information on revaccination frequency

Side Effects of Lyme Disease Vaccine

No major side effects exist with the Lyme disease vaccine in healthy dogs. As with any vaccines, some dogs may have sensitivity after the vaccine, or they can develop some form of a vaccine reaction. Symptoms of a more serious vaccine reaction can include:

  • Pain &/or swelling at the injection site
  • Hives or red patches on the stomach
  • Swelling of the face
  • Trouble breathing

Prices of Lyme Vaccine For Dogs

$20.00 -$40.00

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