Lyme Disease Vaccine For Dogs

Lyme disease is a tick-borne infection, caused by the bacterium Borrelia burgdorferi. Lyme disease is found on multiple continents, including North America, Europe, and Asia. Within the U.S., Lyme disease was first observed in the Northeast and remains most common in that area; however, it is now found across much of the country.  Lyme disease is the most common tick-borne infection diagnosed in dogs in the United States. In 2019, 5 percent of canine blood samples sent to a reference laboratory for Lyme disease testing were positive for infection.

Clinical signs of Lyme disease vary significantly. In many dogs, Lyme disease is completely asymptomatic. These dogs show no signs of illness. Approximately 10 percent of infected dogs, however, develop clinical signs of Lyme disease several months after being bit by an infected tick . Common clinical signs of Lyme disease in dogs include fever, lethargy, and limping. Dogs with mild signs can typically be treated successfully with antibiotics. A small percentage of infected dogs go on to develop a serious kidney disease, known as Lyme nephritis, which can be fatal despite treatment. 

Features of Lyme Disease Vaccine For Dogs

Although the syndrome now known as Lyme disease was first identified in human patients in 1975, Borrelia burgdorferi (the bacterium that causes the disease) was not identified until 1981. The first canine Lyme vaccine was introduced in 1992 .  The Lyme vaccine for dogs is available at most veterinary clinics, especially in areas where Lyme disease poses a significant threat. Even in low-risk areas, many veterinarians carry this vaccine in order to protect dogs traveling to Lyme-endemic areas. If your veterinarian does not carry this vaccine, they may be able to obtain it for you or direct you to another clinic where you can receive it.  This vaccine does not require a specialist visit and can often be administered with your dog’s other vaccinations at a routine wellness visit.

  • Lyme vaccine designed to target the 2 key outer surface proteins (Osps) involved in disease transmission for a full level of protection
  • Proven to induce borreliacidal antibodies that bind to OspA and OspC, forming a complex that attacks the cell membrane and kills Borrelia burgdorferi 
  • Proven to help prevent clinical disease such as arthritis – as well as at the subclinical level 5
  • High level of protection: no serologic evidence of exposure to Borrelia burgdorferi following challenge with infected
    I. scapularis ticks


 For vaccination of healthy dogs 8 weeks of age or older as an aid in the prevention of clinical disease and subclinical arthritis associated with Borrelia burgdorferi.

Dosage and Administration

  • Subcutaneous injection
  • Two 1 mL doses given 2 to 4 weeks apart
  • Contact your veterinarian or manufacturer for more information on revaccination frequency

Lyme Vaccination Schedule for Dogs

An initial Lyme vaccine can be given as early as 8-9 weeks of age (depending on the manufacturer). After the initial vaccine, a booster vaccine must be given 3-4 weeks later. The dog is considered to be protected against Lyme disease four weeks after receiving the second Lyme vaccination. 

For long-term protection, the Lyme vaccine must be repeated once annually for the remainder of your dog’s life. If your dog is significantly overdue for its annual booster, your veterinarian may recommend restarting the initial two-vaccine series.

Side Effects of Lyme Disease Vaccine

No major side effects exist with the Lyme disease vaccine in healthy dogs. As with any vaccines, some dogs may have sensitivity after the vaccine, or they can develop some form of a vaccine reaction. Symptoms of a more serious vaccine reaction can include:

  • Pain &/or swelling at the injection site
  • Hives or red patches on the stomach
  • Swelling of the face
  • Trouble breathing

Prices of Lyme Disease Vaccine For Dogs

$ 44.00 – $58.99

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