Ivermectin Plus (ivermectin and clorsulon) is indicated for the treatment and control of gastrointestinal roundworms (including inhibited Ostertagia ostertagi larvae), lungworms, adult liver flukes, grubs (note insert precautions), sucking lice, and mange mites (cattle scab [note insert indications]). See package insert for complete indications and use directions. The dosage level of clorsulon supplied by Ivermectin Plus is effective only against adult liver flukes (Fasciola hepatica).
IVOMEC Plus is a ready-to-use sterile solution containing 1% w/v ivermectin, 10% clorsulon, 40% glycerol formal, and propylene glycol, q.s. ad 100%. It is formulated to deliver the recommended dose level of 200 mcg ivermectin/kg and 2 mg clorsulon/kg given subcutaneously behind the shoulder at the rate of 1 mL per 110 lb (50 kg) body weight.
Mode Of Action
Ivermectin is a member of the macrocyclic lactone class of endectocides which have a unique mode of action. Compounds of the class bind selectively and with high affinity to glutamate-gated chloride ion channels which occur in invertebrate nerve and muscle cells. This leads to an increase in the permeability of the cell membrane to chloride ions with hyperpolarization of the nerve or muscle cell, resulting in paralysis and death of the parasite. Compounds of this class may also interact with other ligand-gated chloride channels, such as those gated by the neurotransmitter gamma-aminobutyric acid (GABA).
Uses/benefits of Ivermectin Plus Injectable
• Broad Spectrum: combines ivermectin for internal and external parasite control and clorsulon, which effectively controls adult liver flukes in beef and dairy cattle • Convenient: single, small volume dose required • Effective: causes paralysis and death of parasites and helps prevent reinfection • Package safety: rigid plastic vials provide for a firm grip and prevent breakage, individual vial cartons protect vial contents from sunlight • Economical: inexpensive on a cost per dose basis • Safe: approved by FDA
IVOMEC Plus should be given only by subcutaneous injection at a dose volume of 1 mL per 110 lb (50 kg) body weight. This volume will deliver 10 mg ivermectin and 100 mg clorsulon. For example:
Body Weight (lb)
IVOMEC Plus (ivermectin and clorsulon) Injection is to be given subcutaneously only. Animals should be appropriately restrained to achieve the proper route of administration. Use of a 16-gauge, 1/2” to 3/4” sterile needle is recommended. Inject the solution subcutaneously (under the skin) behind the shoulder