Ivermectin Injectable For Rabbits

Ivermectin is an injectable parasiticide for cattle and swine. One low-volume dose effectively treats and controls the following internal and external parasites that may impair the health of cattle and swine: gastrointestinal roundworms (including inhibited Ostertagia ostertagi in cattle), lungworms, grubs, sucking lice, and mange mites of cattle; and gastrointestinal roundworms, lungworms, lice, and mange mites of swine. vermectin is an anti-parasitic drug developed during the 1970s as a partnership between the Kitasato Institute in Japan and Merck & Co. The project was led by Satoshi Omura and William Campbell on each side respectively. Given its broad spectrum against internal and external parasites that improved animal health and boosted productivity, ivermectin quickly became a blockbuster drug in the veterinary field.

During the 1970s, the world was waging a war against river blindness, also known as onchocerciasis, a disease caused by the Onchocerca volvulus parasite in rural areas that crippled whole communities. Some success had already been achieved thanks to the involvement of the World Bank. But once ivermectin was commercialized, it was noticed that Onchocerca cervicalis, the agent of onchocerciasis in horses, practically disappeared in areas where the new drug was used.

Description

Ivermectin is derived from the avermectins, a family of potent, broad-spectrum antiparasitic agents isolated from fermentation of Streptomyces avermitilis. IVERMECTIN Injection is a clear, ready-to-use, sterile solution containing 1% ivermectin, 40% glycerol formal, and propylene glycol, q.s. ad 100%. IVERMECTIN Injection is formulated to deliver the recommended dose level of 200 mcg ivermectin/kilogram of body weight in cattle when given subcutaneously at the rate of 1 mL/110 lb (50 kg). In Swine, IVERMECTIN Injection is formulated to deliver the recommended dose level of 300 mcg ivermectin/kilogram body weight when given subcutaneously in the neck at the rate of 1 mL per 75 lb (33 kg).

Uses/benefits of Ivermectin Injectable For Rabbits

  • Ivermectin (Stromectol) is an antihelmintic (anti-worm) medication
  • Binds selectively to glutamate-gated chloride ion channels in invertebrate nerve and muscle cells, which leads to increased cell membrane permeability to chloride ions, which then causes hyperpolarization of the nerve or muscle cell and parasitic death.
  • Can be used for onchocerciasis, strongyloidiasis, ascariasis, filariasis, gnathostomiasis, lice, scabies and more.
    • Ivermectin does not have activity versus the adult Onchocerca volvulus parasite.
  • Available topical and oral for humans
    • In severe circumstances when humans require injectable ivermectin, it can be acquired from a livestock store. See example picture above. This usually requires some form of informed consent and/or institutional approval.
  • Commonly given as a single dose or two doses
    • Dose depends on indication, but a common dose is 200 mcg/kg
    • Manufacturer does not give dose adjustment for kidney or liver dysfunction
  • May cause Mazzoti reaction with onchocerciasis: reaction to proteins released by dying onchocerca, which can lead to fever, rash, ocular damage, joint or muscle pain, lymphangitis, hypotension, respiratory distress and prostration.
  • Some of the more common adverse effects are: pruritis (itching), fever, rash, lymph node tenderness/enlargement, arthralgia/synovitis and tachycardia
  • Pregnancy category: C

Mode Of Action

Ivermectin is a member of the macrocyclic lactone class of endectocides which have a unique mode of action. Compounds of the class bind selectively and with high affinity to glutamate-gated chloride ion channels which occur in invertebrate nerve and muscle cells. This leads to an increase in the permeability of the cell membrane to chloride ions with hyperpolarization of the nerve or muscle cell, resulting in paralysis and death of the parasite. Compounds of this class may also interact with other ligand-gated chloride channels, such as those gated by the neurotransmitter gamma-aminobutyric acid (GABA)

The margin of safety for compounds of this class is attributable to the fact that mammals do not have glutamate-gated chloride channels, the macrocyclic lactones have a low affinity for other mammalian ligand-gated chloride channels and they do not readily cross the blood-brain barrier.

Prices of Ivermectin Injectable For Rabbits

 $39.95 – $42.95

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