E Coli Vaccine For Pigs

E. coli enterotoxicosis is one of the main causes of neonatal diarrhea in piglets. For their protection against this disease a vaccine has been prepared based on K88 and LT. Pregnant sows were vaccinated, thereby transferring passive immunity to their offspring through colostrum and milk. Protection was obtained in terms of decrease in mortality, occurrence of diarrhea and excretion of enteropathogenic bacteria.

Piglets from non-immune sows could be immunized shortly after birth. However, piglets from immune sows vaccinated once after birth failed to show an active antibody response; only by two vaccinations, 4 weeks apart, was an antibody formation induced. From the results presented it is concluded that a proper vaccination schedule makes it possible to immunize piglets from both immune and non-immune sows and induce protection against post-weaning diarrhea.


Piglets are exposed to Escherichia coli, a common bacterium of the gut, within minutes of birth. A number of strains of this common bowel bacterium are pathogenic for pigs. Unless the piglet receives adequate supplies of maternal colostrum, which is rich in antibodies to, these E. coli strains, then infection may occur. Good hygiene and temperature control in the farrowing crates are essential in controlling and preventing E.coli scours. Vaccination of sows with E. coli pilus antigens stimulates them to produce protective antibodies that are passed to the piglets via the colostrum. These antibodies coat the intestinal lining and prevent pathogenic E. coli from attaching to the gut wall and causing disease.

Neonatal diarrhoea by E. coli can be prevented through colostral immunity induced by vaccination of pregnant sows. The immunity induced by these vaccines, however, disappears after weaning. The commercial vaccines currently available are based on inactivated bacterins or purified fimbrial subunits, and some even contain thermolabile enterotoxins (LT) for parenteral administration.

The first contact of the pregnant gilt with the vaccine should include two doses in order to stimulate an enhanced immune response. Vaccination of multiparous sows is recommended two weeks before farrowing. Passive immunization through colostral antibodies protects piglets from developing ETEC diarrhoea until weaning. The success of the immunisation programs lies in the use of vaccines that contain specific fimbrial antigens present in the strains circulating in each farm. To this end, genotyping of ETEC isolates obtained from each particular case could be of great benefit. In addition, a good management of piglets’ colostrum intake is mandatory.

Features of E Coli Vaccine For Pigs

Vaccination involves exposing the pig to the protein components (called the antigen) of the infectious agent. Some vaccines contain living organisms that have been altered so that they cannot produce disease but still produce an immunity. Most contain killed or inactivated organisms. The immune system responds by producing antibodies that destroy the infectious agents, usually in co-operation with specialised body cells or by neutralising the toxins that are responsible for the disease. This process of stimulating immunity is called vaccination. Vaccines contain antigens from viruses, bacteria, bacterial toxins, or parasites. They are given to pigs, usually by injection, to stimulate an immune response which will protect the pigs against later natural infection with the organism from which the vaccine was derived. Most stimulate both a humoral response and a cell-mediated response. Vaccines can either contain viable organisms that will multiply in the pig, or inactivated ones that will not multiply in the pig.

dema Vac F18-E.coli vaccine for pigs is given orally as an aid in the prevention of edema disease caused by F18-positive E. coli. The receptor necessary to allow pigs to be actively vaccinated develops in most pigs between 15 and 20 days of age. Some herds that experience excess mortality may benefit from a second vaccination to account for this variation. In recent field studies, ARKO’s Edema Vac demonstrated efficacy against virulent F-18 E. Coli by decreasing mortality associated with edema disease by nearly 99%. Vaccine should be administered at 18 days of age or older.

Prices of E Coli Vaccine For Pigs

$30.00-$90.00/ Piece

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