Rabbits are often used as animal models for experimental purposes; in many cases steroid-induced immunosuppression is necessary. The aim of this study was to characterise a model of immunosuppression in rabbits, based on changes in the lymphocyte subset distribution, changes in proliferative capacity of lymphocytes and activity of neutrophils 1, 3 and 7 days after the administration of 2 mg/kg dexamethasone phosphate (DXP) three times at 6-h intervals. In peripheral blood, neutrophilia and lymphopenia together with eosinopenia, monocytopenia and basopenia in the absence of leukocytosis was detected. One day after DXP administration the absolute numbers of all lymphocyte subsets decreased in the blood, whereas in bone marrow, absolute numbers of all lymphocyte subsets increased significantly, except CD79α+ cells that increased only in relative numbers
Bacterial meningitis continues to be associated with high mortality and neurologic sequelae rates worldwide. Neurologic sequelae include epileptic seizures, mental retardation, and learning disorders. The impairment of the CNS is caused by stimulation of the host’s systemic and local immune defense (invasion of leukocytes, activation of resident immune cells such as microglia, dysfunction of the blood-brain barrier, release of cytokines) and by direct toxicity of bacterial products (1). Standard therapy for bacterial meningitis is based on high doses of bactericidal cell wall–acting antibiotics such as β-lactams or vancomycin, which act by bacteriolysis. Despite rapid sterilization of the CSF, worsening of clinical symptoms after initiation of antibiotic treatment during meningitis has been frequently observed, most probably as a consequence of a burst of inflammation caused by the liberation of proinflammatory bacterial compounds
Current treatment options for dry eye syndrome include multipledoses of topical anti-inflammatory drugs. To evaluate the effectivenessof a single iontophoretic dose of a corticosteroid for treatingConcanavalin A (Con A) induced dry eye in rabbits.
Features of Dexamethasone For Rabbits
Before taking dexamethasone, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details. Before using this medication, tell your doctor or pharmacist your medical history, especially of: infections (such as tuberculosis, herpes, fungal infections), kidney disease, liver disease, mental/mood disorders (such as psychosis, anxiety, depression), mineral imbalance (such as low level of potassium/calcium in the blood), thyroid disease, stomach/intestinal problems (such as ulcer, ulcerative colitis, diverticulitis, unexplained diarrhea), high blood pressure, heart problems (such as heart failure, recent heart attack), diabetes, eye diseases (such as cataracts, glaucoma), bone loss (osteoporosis), blood clots.
Using corticosteroid medications for a long time can make it more difficult for your body to respond to physical stress. Before having surgery or emergency treatment, or if you get a serious illness/injury, tell your doctor or dentist that you are using this medication or have used this medication within the past 12 months. Tell your doctor right away if you develop unusual/extreme tiredness or weight loss. If you will be using this medication for a long time, carry a warning card or medical ID bracelet that identifies your use of this medication.
Uses/benefits of Dexamethasone For Rabbits
Dexamethasone is used to treat conditions such as arthritis, blood/hormone disorders, allergic reactions, skin diseases, eye problems, breathing problems, bowel disorders, cancer, and immune system disorders. It is also used as a test for an adrenal gland disorder (Cushing’s syndrome).Dexamethasone belongs to a class of drugs known as corticosteroids. It decreases your immune system’s response to various diseases to reduce symptoms such as swelling and allergic-type reactions.
Prices of Dexamethasone For Rabbits
$17.35 – $33.95