Decoquinate is a 4-hydroxyquinolone coccidiostat that inhibits electron transport in protozoal mitochondria and interferes with sporozoite development. It likely has a similar mechanism of action to atovaquone, because resistance to atovaquone can result in cross-resistance to decoquinate. Although developed as a food additive for use in production animals, decoquinate can be used successfully and without adverse effects to prevent relapses in dogs that are chronically infected with Hepatozoon americanum. Decoquinate also appeared to be effective for treatment of Sarcocystis spp. myositis in a dog. Its distribution and metabolism in dogs and cats have not been described
CattleBovine coccidiosis is one of the most common and importantdisease of cattle worldwide (Daugschies & Najdrowski, 2005).Eimeria infections have been observed in almost all areas wherecattle are raised and are usually of greatest importance in calves<1 year of age. Cattle reared under conventional cattle farmingsystems are exposed and become infected early in life. All agegroups of cattle are susceptible to infection, but clinical signs ofdiarrhoea, often bloody, are most common in young calvesreared under intensive husbandry conditions, and more commonin housed animals than those on pasture
Features of Decoquinate For Cattle
For the prevention of coccidiosis in ruminating and non-ruminating calves (including veal calves) and cattle caused by Eimeria bovis and E. zuernii. Thoroughly mix Deccox into the ration at a rate to provide 22.7 mg decoquinate per 100 lbs (0.5 mg per kg) body weight per day. Feed for at least 28 days during periods of coccidiosis exposure or when experience indicates that coccidiosis is likely to be a hazard. Coccidiostats are not indicated for use in adult animals due to continuous previous exposure.
Cattle – Prevention of coccidiosis in ruminating and nonruminating calves (including veal calves) and cattle caused by Eimeria bovis and E zuernii (labeled dosage; FDA-approved): 0.5 mg/kg PO every 24 hours in milk or mixed in feed. Administer for at least 28 days during periods of coccidiosis exposure or when experience indicates that coccidiosis is likely to be a hazard. Coccidiostats are not indicated for use in adult animals due to continuous previous exposure. Treatment of coccidiosis in calves (extra-label): 1 mg/kg in feed PO every 24 hours for at least 28 days. Cryptosporidium in calves (extra-label): 2 mg/kg PO every 12 hours for 21 days.