Chlamydia Vaccine For Sheep

This disease is caused by an organism called Chlamydia psittaci and is one of the biggest causes of abortions and stillbirths in sheep and goats. This organism is found throughout the world, including South Africa. There are other syndromes associated with this disease, for example, respiratory tract and digestive tract infections. The organism may infect a wide range of hosts including cattle, birds and humans.

Ovilis Enzovax is a live, attenuated vaccine containing >- 105.0 IFU of Chlamydia psittaci per dose. Ovilis Enzovax is indicated for the active immunisation of susceptible breeding female sheep as an aid in the prevention of abortion and stillbirths by Chlamydia psittaci infection.

Description

Chlamydia abortus, the aetiological agent of enzootic abortion of ewes, is a major cause of reproductive loss in small ruminants worldwide, accounting for significant economic losses to the farming industry. Disease can be managed through the use of commercial inactivated or live whole organism-based vaccines, although both have limitations particularly in terms of efficacy, safety and disease-associated outbreaks. Here we report a comparison of two experimental vaccines (chlamydial outer membrane complex (COMC) and octyl glucoside (OG)-COMC) based on detergent extracted outer membrane preparations of C. abortus and delivered as prime-boost immunisations, with the commercial live vaccine Cevac® Chlamydia in a pregnant sheep challenge model.

No abortions occurred in either experimental vaccine group, while a single abortion occurred in the commercial vaccine group. Bacterial shedding, as a measure of potential risk of transmission of infection to naïve animals, was lowest in the COMC vaccinated group, with reductions of 87.5%, 86.4% and 74% observed for the COMC, OG-COMC and live commercial vaccine groups, respectively, compared to the unvaccinated challenge control group. The results show that the COMC vaccine performed the best and is a safer efficacious alternative to the commercial vaccines. However, to improve commercial viability, future studies should optimise the antigen dose and number of inoculations required

Feature sof Chlamydia Vaccine For Sheep

Ewes should be vaccinated at least 4 weeks before mating. Ewe lambs intended for breeding can be vaccinated from 5 months of age. Do not vaccinate pregnant animals or animals which are being treated with antibiotics, particularly tetracyclines.

Dosage & Administration

Dose: 2 ml by intramuscular or subcutaneous injection.

Ewe lambs, where it is intended to breed from them, may be vaccinated from 5 months of age.

Shearlings and older ewes should be vaccinated during the 4 month period prior to mating.

Prices of Chlamydia Vaccine For Sheep

$14.34 – $59.58

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