Cattle botulism is a fatal intoxication caused by botulinum neurotoxins (BoNTs) produced by Clostridium botulinum serotypes C and D resulting in economic losses. Vaccination is the most effective way to control botulism. However, the commercially available vaccines are difficult and hazardous to produce. Neutralizing antibodies against the C-terminal fragment of the BoNT heavy chain (HC) are known to protect against lethal doses of BoNTs. We report the vaccination of cattle with a previously tested recombinant chimera consisting of Escherichia coli heat-labile enterotoxin B subunit and the HC of BoNTs C and D
Botulism is caused by Clostridium botulinum bacteria that produce toxins under certain environmental conditions. The bacteria are commonly found in the environment and will grow to high levels in decaying organic matter including animal and bird carcases. It is believed that contamination of broiler litter with the carcases of chickens that have died, from various causes during production, can render the litter dangerous for ruminants.
Even small fragments of carcases transferred onto pasture by scavenger animals, such as foxes, dogs or crows may pose a risk to grazing ruminants. Scavengers may gain access to this material during storage or following spreading on land. While the Animal By-Products (Enforcement) Regulations (NI) 2015 permits the spreading on land of poultry litter, the spreading of litter contaminated by carcases is an offence under the Regulations.
Features of Botulism Vaccine Cattle
Longrange® replaces the need to use two initial doses of vaccine. Longrange® provides cattle producers with an effective, economical and safe vaccine, providing protection for their cattle while saving on expensive mustering costs and eliminating the expense of a second dose.
Trials in northern Australia have also shown that site reactions following vaccination with Longrange® were minimal.
Longrange® does not clog or block vaccinators, so the purchase of new or special vaccinators is not required.
Benefits of Botulism Vaccine Cattle
Provides active immunisation against botulism
Generates protective levels of circulating antibodies for at least 36 months
Only one initial injection required
Suitable for use in cattle
Dosage and administration
The recommended dose for cattle of all ages is 2.5mL.