Antihistamine For Goats

Antihistamines block either H1 or H2 receptors. H1 receptors are responsible for pruritus, increased vascular permeability, release of inflammatory mediators, and attraction of inflammatory cells. H1 blockers act by competing with histamine for H1-receptor sites on effector cells (they do not block release of histamine but can antagonize its effects). They also have anticholinergic, sedative, and local anesthetic effects and vary greatly in their potency, dosage, incidence of adverse effects, and cost.

Second-generation H1 blockers (eg, terfenadine, cetirazine, loratadine, astemazole) are less likely to cross the blood-brain barrier, or they have a low affinity for brain compared with peripheral H1 receptors. They have not proved useful to date in controlling pruritus in small animals. Responses to antihistamines vary considerably, and several trials may be necessary to find one effective for an animal Antihistamines may act synergistically with NSAIDs, glucocorticoids, or fatty acid supplements and may allow dosages of these agents to be reduced in some cases

Description

First-generation antihistamines may cause drowsiness or GI signs (eg, vomiting, diarrhea). Overdoses may cause CNS hyperexcitability and may be fatal. Anticholinergic properties lead to hypertension (and thus contraindicated in cardiac patients), dry mouth, blurred vision (contraindicated in glaucoma), and urinary retention. Hydroxyzine is teratogenic. They may also stimulate appetite (particularly cyproheptadine).

Second-generation antihistamines are cardiotoxic at high doses. High doses of terfenadine and astemizole lead to prolonged QT intervals and arrhythmias (eg, ventricular tachycardia, cardiac arrest). Cardiotoxicity has been reported only as a result of overdose in animals with impaired hepatic metabolism.

Antihistamine Indications

As an aid in the treatment of allergies and other conditions in which it is desirable to neutralize histamine in cattle, horses, sheep, swine, dogs and cats.

Active Ingredients

per mL
Pyrilamine maleate25 mg
Ephedrine hydrochloride10 mg

PRESERVATIVE:

Benzyl alcohol2% (V/V)

DOSAGE: For intramuscular and intravenous use.

Cattle, horses, sheep and swine: Administer 1 mL per 45 kg of body weight.

Dogs and cats: Administer 0.5 mL per 10 kg of body weight.

When used intramuscularly, doses may be repeated every 2 hours if necessary.

Warning

Treated animals must not be slaughtered for use in food for at least 7 days after the latest treatment with this drug. Milk taken from treated animals during treatment and within 48 hours after the latest treatment with this drug must not be used as food.

Prices of Antihistamine For Goats

$29.99 – $59.95

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