Amoxicillin is a broad spectrum penicillin antibiotic used to treat certain bacterial infections in poultry. Amoxicillin has activity against penicillin-sensitive Gram-positive bacteria, as well as some Gram-negative bacteria. The gram-positive spectrum of activity includes alpha- and beta-hemolytic streptococci, some Staphylococci species, and Clostridia species. Amoxicillin is also effective against Escherichia coli (E. coli), many strains of Salmonella, and Pasteurella multocida. Amoxicillin is most commonly given to birds who were recently attacked by a predator, to help prevent pasteurellosis (fowl cholera) from bites or scratches.
AMOXICILLIN SP is a soluble powder containing 800 mg/g amoxicillin trihydrate (equivalent to 697 mg amoxicillin). AMOXICILLIN SP will not block nipple drinkers or water lines. The maximum solubility of AMOXICILLIN SP is 3 g/litre, although solubility may be increased by use of water conditioner powder.
Egg Withdrawal Period:
1 day withdrawal period for eating eggs.
Amoxicillin capsules, tablets, and powder for oral suspension should be stored at room temperature (15-30°C) in tight containers. After reconstitution, the oral suspension should preferably be refrigerated (refrigeration not absolutely necessary) and any unused product discarded after 14 days. After reconstitution, the injectable veterinary suspension is stable for 3 months at room temperature and 12 months when refrigerated.
Dosage and Administration
It is recommended to administer AMOXICILLIN SP once daily via the drinking water, using either a tank or water proportioner. It is advisable to restrict drinking water for approximately 2 hours (less in hot weather) prior to medication. Each 15 ml measure (provided in the packaging) will contain approximately 10 grams of AMOXICILLIN SP.
Amoxicillin/clavulanate – 125-250 mg/kg PO q8-12h or 500 mg/L drinking water (B Speer).
Amoxicillin sodium – 50-250 mg/kg IM, IV q8-12h (B Speer).
Amoxicillin trihydrate – 55-200 mg/kg PO, SC, IM, IV q4-12 h or 200-1500 mg/L drinking water (B Speer).